Haematologica
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Haematologica, Vol 79, Issue 1, 83-85
Copyright © 1994 by Ferrata Storti Foundation

Case Reports

Trisomy 4 and ring chromosome in a patient with acute myelomonocytic leukemia

L Vicari, L Sebastio, MC Stanziola, A Fasanaro, and F Ferrara

Medical Genetics Service, Cardarelli Hospital, Naples, Italy.

We describe a patient with acute myelomonocytic leukemia (AMML) in whom cytogenetic analysis revealed trisomy 4 associated with a ring chromosome. In addition, in a cytogenetically unrelated clone, trisomy 8 and 5q- abnormalities were detectable. The possibility of a subclinical myelodysplastic syndrome preceding the onset of AML is discussed on the basis of the morphological and cytogenetic findings.




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Copyright © 1994 by the Ferrata Storti Foundation.