Haematologica
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Haematologica, Vol 79, Issue 2, 154-164
Copyright © 1994 by Ferrata Storti Foundation

Journal Article

Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?

R Bellazzi, C Siviero, and R Bellazzi

Dipartimento di Informatica e Sistemistica, Universita di Pavia, Italy.

This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.




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Copyright © 1994 by the Ferrata Storti Foundation.