Haematologica
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Haematologica, Vol 79, Issue 4, 371-373
Copyright © 1994 by Ferrata Storti Foundation

Case Reports

Thrombotic thrombocytopenic purpura: a rare late complication of allogeneic bone marrow transplantation

G Pucci, M Martino, F Morabito, P Iacopino, W Arcese, AP Iori, VT Lombardo, A L'Abbate, M Santostefano, and F Nobile

Department of Hematology, OORR, Reggio Calabria, Italy.

Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) usually occurs in a setting of systemic infection or graft-versus-host reaction during the first weeks following transplant. We report a case of fatal TTP that developed eight months after allogeneic bone marrow transplantation (BMT) without any evident association with other transplantation-related complications. Conditioning chemotherapy could have induced the disorder by causing damage to the vascular endothelium. The removal of immunosuppression, including cessation of cyclosporin A (CyA), may have precipitated the disease.




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Copyright © 1994 by the Ferrata Storti Foundation.