Haematologica
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Haematologica, Vol 79, Issue 6, 536-539
Copyright © 1994 by Ferrata Storti Foundation

Case Reports

Application of fluorescence in situ hybridization in defining a complex t(9;21;22) Ph formation

M Mancini, M Nanni, M Cedrone, MR De Cuia, MB Rondinelli, F Malagnino, and G Alimena

Department of Human Biopathology, University La Sapienza, Rome, Italy.

We describe the application of fluorescence in situ hybridization (FISH) in a case of suspected chronic myelogenous leukemia (CML), cytogenetically characterized by a t(21;22) with no clear involvement of chromosome 9. The dual color FISH technique, performed using specific painting probes for chromosomes 9,21,22 and a BCR/ABL translocation probe, enabled us to confirm the diagnosis of CML by detecting the BCR/ABL rearrangement on chromosome 22q and the involvement of chromosome 9 in a variant translocation t(9;21;22).




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Copyright © 1994 by the Ferrata Storti Foundation.