Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Camaschella, C
Right arrow Articles by Cappellini, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Camaschella, C
Right arrow Articles by Cappellini, M.
Haematologica, Vol 80, Issue 1, 58-68
Copyright © 1995 by Ferrata Storti Foundation

Journal Article

Thalassemia intermedia

C Camaschella and MD Cappellini

Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino, Ospedale S. Luigi Gonzaga, Italy.

Thalassemia intermedia is a clinical definition applied to patients whose clinical phenotype is milder than that of thalassemia major. Criteria used to define thalassemia intermedia including age at presentation, hemoglobin or fetal hemoglobin levels and transfusion independence, are unsatisfactory. The possibility of typing the molecular defect allows a retrospective analysis of patients and offers a new tool for the diagnosis of thalassemia intermedia. Nevertheless, because of several factors that interact in the disease expression, the beta-genotype alone is not predictive of the phenotype in all cases. Although benign, the clinical course of thalassemia intermedia is characterized by several complications that can be prevented by an accurate follow-up. The conventional treatment of thalassemia intermedia remains controversial; it is hoped that recent advances in the pharmacological manipulation of hemoglobin switching will offer a therapeutic option in the future, at least to selected patients.


This article has been cited by other articles:


Home page
 haematolHome page
A. H. Nassar, M. Naja, C. Cesaretti, B. Eprassi, M. D. Cappellini, and A. Taher
Pregnancy outcome in patients with {beta}-thalassemia intermedia at two tertiary care centers, in Beirut and Milan
Haematologica, October 1, 2008; 93(10): 1586 - 1587.
[Full Text] [PDF]

Home page
 haematolHome page
A. Aessopos, M. Kati, and D. Farmakis
Heart disease in thalassemia intermedia: a review of the underlying pathophysiology
Haematologica, May 1, 2007; 92(5): 658 - 665.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Vaccari, R. Crepaz, M. Fortini, M. R. Gamberini, S. Scarcia, W. Pitscheider, and G. Bosi
Left Ventricular Remodeling, Systolic Function, and Diastolic Function in Young Adults With {beta}-Thalassemia Intermedia : A Doppler Echocardiography Study
Chest, February 1, 2002; 121(2): 506 - 512.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
N. F. Olivieri
The {beta}-Thalassemias
N. Engl. J. Med., July 8, 1999; 341(2): 99 - 109.
[Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 1995 by the Ferrata Storti Foundation.