Haematologica
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Haematologica, Vol 80, Issue 4, 341-343
Copyright © 1995 by Ferrata Storti Foundation

Case Reports

Treatment of a delayed graft failure after allogeneic bone marrow transplantation with IL-3 and GM-CSF

AM Vannucchi, A Bosi, D Laszlo, S Guidi, R Saccardi, and P Rossi-Ferrini

Division of Hematology, University of Florence, Ospedale di Careggi, Italy.

We report on the partial effectiveness of sequential IL-3 and GM-CSF administration, following an ineffective 5-day trial with G-CSF, in a case of delayed graft failure after allogeneic bone marrow transplantation. Therapy with these growth factors was followed by a prompt (within 2 days) increase of neutrophil count, suggesting the possibility of a priming effect due to the previous G-CSF administration. The potential usefulness of this growth factor schedule administration in the treatment of graft failures after allogeneic bone marrow transplantation requires confirmation in controlled trials.


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[Abstract] [Full Text]


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Copyright © 1995 by the Ferrata Storti Foundation.