Haematologica
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Haematologica, Vol 80, Issue 5, 431-433
Copyright © 1995 by Ferrata Storti Foundation

Comparative Study

Serum interleukin-8 levels in thalassemia intermedia

F Dore, S Bonfigli, S Pardini, and M Longinotti

Istituto di Ematologia, Universita di Sassari, Italy.

In this study we determined serum IL-8 levels in 18 untransfused patients with beta-thalassemia intermedia and in 14 subjects affected by HbH disease. As reported in polytransfused homozygous beta-thalassemia, untransfused beta-thalassemia and HbH disease show significantly (p < 0.005) higher serum IL-8 levels than normal controls. Our data suggests that there could be an intrinsic cause for the IL-8 increase in thalassemia intermedia. We think than the hyperactivity of thalassemic macrophages related to chronic hemolysis is the main cause for the increment in cytokines, such as IL-8, found in thalassemic syndromes.


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A. Aessopos, D. Farmakis, and D. Loukopoulos
Elastic tissue abnormalities resembling pseudoxanthoma elasticum in beta thalassemia and the sickling syndromes
Blood, January 1, 2002; 99(1): 30 - 35.
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Copyright © 1995 by the Ferrata Storti Foundation.