Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vianelli, N
Right arrow Articles by Tura, S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vianelli, N
Right arrow Articles by Tura, S
Haematologica, Vol 81, Issue 1, 3-7
Copyright © 1996 by Ferrata Storti Foundation

Journal Article

Increased P-selectin plasma levels in patients with thrombotic thrombocytopenic purpura

N Vianelli, L Catani, L Gugliotta, F Nocentini, S Baravelli, G Lancellotti, and S Tura

Hematology Institute "Seragnoli", University of Bologna, Italy.

BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a rare vascular disorder of unknown etiology. There is evidence to support the hypothesis that platelets and endothelium play a pivotal pathogenetic role. Immunological assays for plasma thrombomodulin and P-selectin levels have recently been made available and they allow simple evaluation of endothelial damage and endothelial/platelet activation, respectively. In this study, we measured the plasma levels of thrombomodulin, P-selectin and von Willebrand factor in 9 TTP patients during active disease and at the time of complete remission (CR). METHODS: Thrombomodulin, P-selectin and von Willebrand factor were measured by enzyme immunoassay. RESULTS: Mean thrombomodulin and von Willebrand factor plasma values were always within the normal range. P-selectin plasma levels, both in the active phase of the disease and in CR (median 312 and 185 ng/mL, respectively), were significantly higher than in normal controls (mean 96 +/- 35 ng/mL, mean 88 ng/mL; p < 0.05). However, the mean value of P-selectin in CR (median 185 ng/mL) was significantly lower than that observed at diagnosis (p < 0.05). In addition, an inverse relationship between P-selectin plasma levels and platelet count (r = -0.526; p = 0.03) was observed. CONCLUSIONS: These findings suggest that activation of platelets and/or endothelium may play a relevant role in the pathogenesis of TTP.


This article has been cited by other articles:


Home page
 CLIN APPL THROMB HEMOSTHome page
M. Cleanthis, J. Smout, V. Bhattacharya, H. Ashour, A. Dyker, G. Ashley Ford, D. P Mikhailidis, and G. P. Stansby
Soluble but Not Platelet P-selectin Correlates With Spontaneous Platelet Aggregation: A Pilot Study
Clinical and Applied Thrombosis/Hemostasis, April 1, 2008; 14(2): 227 - 233.
[Abstract] [PDF]

Home page
 Eur Heart JHome page
A. D. Blann, S. K. Nadar, and G. Y.H. Lip
The adhesion molecule P-selectin and cardiovascular disease
Eur. Heart J., December 2, 2003; 24(24): 2166 - 2179.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
H. M. Amin, S. Ahmad, J. M. Walenga, D. A. Hoppensteadt, H. Leitz, and J. Fareed
Soluble P-Selectin in Human Plasma: Effect of Anticoagulant Matrix and its Levels in Patients With Cardiovascular Disorders
Clinical and Applied Thrombosis/Hemostasis, April 1, 2000; 6(2): 71 - 76.
[Abstract] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 1996 by the Ferrata Storti Foundation.