Haematologica
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Haematologica, Vol 81, Issue 1, 59-61
Copyright © 1996 by Ferrata Storti Foundation

Clinical Trial

Fractionated infusions of cryopreserved stem cells may prevent DMSO-induced major cardiac complications in graft recipients

M Martino, F Morabito, G Messina, G Irrera, G Pucci, and P Iacopino

Dipartimento di Emato-Oncologia, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.

The amount of transfused dimethyl sulfoxide (DMSO) is indicated as the major cause of the cryoprotectant-related toxicity in autologous stem cell recipients, with a high incidence of major cardiac side effects. In this study we tried to discover whether fractionated infusion of the total graft volume could prevent the DMSO-related major cardiovascular side effects. We conclude that continuous cardiac monitoring during and after fractionated infusions of DMSO-containing graft documented no major arrhythmias, with only seven episodes of asymptomatic sinus bradycardia.


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[Abstract] [Full Text] [PDF]


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Copyright © 1996 by the Ferrata Storti Foundation.