Haematologica
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Haematologica, Vol 89, Issue 10, 1271-1273
Copyright © 2004 by Ferrata Storti Foundation

Letter

Molecular detection of minimal residual disease is associated with early relapse in adult acute lymphoblastic leukemia

G Specchia, A Liso, A Pannunzio, F Albano, A Mestice, D Pastore, and V Liso

Several studies in childhood acute lymphoblastic leukemia (ALL) have documented that molecular detection of minimal residual disease (MRD) based on screening for T-cell receptor and immunoglobulin gene rearrangements can identify patients at a high risk of relapse. In our experience, evaluation of MRD in adult ALL can help to identify high risk patients.


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M. J. Borowitz, M. Devidas, S. P. Hunger, W. P. Bowman, A. J. Carroll, W. L. Carroll, S. Linda, P. L. Martin, D. J. Pullen, D. Viswanatha, et al.
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study
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