Haematologica
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Haematologica, Vol 89, Issue 11, 1399-1401
Copyright © 2004 by Ferrata Storti Foundation

Letter

Overexpression of Her2/neu is observed in one third of adult acute lymphoblastic leukemia patients and is associated with chemoresistance in these patients

P Chevallier, N Robillard, S Wuilleme-Toumi, F Mechinaud, JL Harousseau, and H Avet-Loiseau

Among 100 patients with acute lymphoblastic leukemia (ALL), 15 B-ALL patients were found positive for surface Her2/neu expression. The incidence in children was only 3.4% compared to 31% in adults (p=0.001). Considering only adult B-ALL patients (n=38), surface Her2/neu expression was associated with chemoresistance (50% versus 11%, p=0.03) suggesting that it could be a prognostic marker of poor clinical outcome in ALL.




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Copyright © 2004 by the Ferrata Storti Foundation.