Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chiusolo, P
Right arrow Articles by Leone, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chiusolo, P
Right arrow Articles by Leone, G
Haematologica, Vol 89, Issue 2, 139-144
Copyright © 2004 by Ferrata Storti Foundation

Comparative Study

Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population

P Chiusolo, G Reddiconto, G Cimino, S Sica, A Fiorini, G Farina, A Vitale, F Sora, L Laurenti, F Bartolozzi, P Fazi, F Mandelli, and G Leone

Istituto di Ematologia, Policlinico Gemelli, Largo A. Gemelli 8, 00168 Rome, Italy. p.chiusolo@rm.unicatt.it

BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and DNA methylation and synthesis. Some genotypes of this highly polymorphic enzyme are associated with decreased activity. Previous studies have suggested that individuals with the MTHFR 677TT, 1298AC and 1298CC have a lower risk of adult acute lymphoblastic leukemia (ALL). DESIGN AND METHODS: In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy. RESULTS: We did not find any association between the different polymorphisms and susceptibility to ALL. In multivariate analysis different genotypes did not show any correlation with the risk of ALL. The adjusted odds ratios and 95% confidence intervals for MTHFR C677T were 0.69 (0.4-1.19) for 677CT versus 677CC wild type, and 0.99 (0.50-1.97) for 677TT versus 677CC. The corresponding values for MTHFR A1298C were 0.93 (0.56-1.53) for 1298AC versus 1298AA wild type and 1.14 (0.36-3.61) for 1298CC versus 1298AA. INTERPRETATION AND CONCLUSIONS: These results do not support the suggestion that populations carrying different genotypes of the two MTHFR polymorphisms, C677T and A1298C, have a different susceptibility to ALL, at least in the Mediterranean area.


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
T. V. Pereira, M. Rudnicki, A. C. Pereira, M. S. Pombo-de-Oliveira, and R. F. Franco
5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Acute Lymphoblastic Leukemia Risk: A Meta-analysis.
Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1956 - 1963.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Friso, D. Girelli, E. Trabetti, O. Olivieri, P. Guarini, P. F. Pignatti, R. Corrocher, and S.-W. Choi
The MTHFR 1298A>C Polymorphism and Genomic DNA Methylation in Human Lymphocytes
Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 938 - 943.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2004 by the Ferrata Storti Foundation.