Haematologica
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Haematologica, Vol 89, Issue 3, 363-364
Copyright © 2004 by Ferrata Storti Foundation

Letter

Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia

C Wuchter, S Richter, D Oltersdorf, L Karawajew, WD Ludwig, and I Tamm

Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-related proteins CD95, Bcl-2, Bax, Bcl-xL, procaspase-3, XIAP, cIAP-1, and survivin differ between children and adults with de novo AML.


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