Haematologica
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Haematologica, Vol 89, Issue 3, 373-375
Copyright © 2004 by Ferrata Storti Foundation

Letter

Allogeneic bone marrow transplantation with non-T-cell-depleted marrow from two HLA-antigen-mismatched related donors

H Ogawa, K Ikegame, M Kawakami, Y Taniguchi, Y Oka, and I Kawase

Allogeneic BMT from 2 antigen-mismatched donors has been difficult to perform without T-cell depletion. Seven patients with advanced-stage hematologic malignancies underwent BMT with intensified graft-versus-host disease prophylaxis consisting of tacrolimus, methotrexate, and methylprednisolone. No rejection or acute GVHD >or= grade III was observed. This preliminary result is very promising.




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Copyright © 2004 by the Ferrata Storti Foundation.