Haematologica, Vol 89, Issue 4, 490-492
Copyright © 2004 by Ferrata Storti Foundation
The impact of the mutations of the HFE gene and of the SLC11A3 gene on iron overload in Greek thalassemia intermedia and beta(s)/beta(thal) anemia patients
M Politou,
V Kalotychou,
M Pissia,
Y Rombos,
N Sakellaropoulos,
and
G Papanikolaou
In this study, we evaluated the impact of mutations of the HFE and ferroportin gene on iron overload in thalassemia intermedia and betas/betathal patients. Neither HFE (C282Y and H63D) nor ferroportin(Val162del) mutations were determinants of total body iron status, as assessed by ferritin levels, in either group of patients.