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Haematologica, Vol 89, Issue 4, 492-493
Copyright © 2004 by Ferrata Storti Foundation

Letter

Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia

G Giribaldi, D Ulliers, E Schwarzer, I Roberts, W Piacibello, and P Arese

Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progenitor growth.


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