Haematologica
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Haematologica, Vol 89, Issue 4, 506-508
Copyright © 2004 by Ferrata Storti Foundation

Letter

B-cell repertoire reconstitution after hematopoietic stem cell transplantation in children evaluated by immunoglobulin heavy chain third complementarity determining region fingerprinting

D Di Martino, S Dallorso, P Terranova, L Scarso, G Morreale, and A Valetto

Immunodeficiency after hematopoietic stem cell transplantation leads to a high risk of opportunistic infections. We evaluated B-lymphocyte reconstitution in 36 children by heavy chain third complementarity determining region (CDR3)-fingerprinting and immunophenotypic analysis. The time necessary to return to the normal immunoglobulin heavy chain-CDR3 polyclonal situation was basically related to the type of transplant and this process did not recapitulate fetal ontogenesis.




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Copyright © 2004 by the Ferrata Storti Foundation.