Haematologica
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Haematologica, Vol 89, Issue 5, 610-611
Copyright © 2004 by Ferrata Storti Foundation


Letter

A new cross-over region for hemogloboin-Lepore-Hollandia

V Chan, P Au, B Yip, and TK Chan

Hb Lepore-Hollandia, identified in a Thai patient, was found to be due to a new cross-over between IVS1-nt 42 and nt 56 of the delta- and beta-globin genes. This differs from a previous case which crossed-over between codon 22 and IVS1-nt 16. Two independent homologous unequal cross-over events account for these two Lepore-Hollandia genes.


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Hum Mol GenetHome page
K. Holloway, V. E. Lawson, and A. J. Jeffreys
Allelic recombination and de novo deletions in sperm in the human {beta}-globin gene region
Hum. Mol. Genet., April 1, 2006; 15(7): 1099 - 1111.
[Abstract] [Full Text] [PDF]




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