Haematologica
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Haematologica, Vol 89, Issue 5, 613-615
Copyright © 2004 by Ferrata Storti Foundation

Letter

No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia

D Gandini, AJ Allen, MJ Nash, DC Linch, and RE Gale

Mutations in the GATA-1 gene have been identified in patients with familial macrothrombocytopenia and Down's syndrome patients with a transient myeloproliferative disorder and/or acute megakaryoblastic leukemia. We screened this gene in 46 patients with essential thrombocythemia and identified only a common single nucleotide polymorphism that is unlikely to be of pathological significance.


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Pathogenesis of Myelofibrosis With Myeloid Metaplasia
J. Clin. Oncol., November 20, 2005; 23(33): 8520 - 8530.
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Copyright © 2004 by the Ferrata Storti Foundation.