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Haematologica, Vol 89, Issue 5, 619-620
Copyright © 2004 by Ferrata Storti Foundation


Letter

Differentiating agents + low-dose chemotherapy in the management of old/poor prognosis patients with acute myeloid leukemia or myelodysplastic syndrome

D Ferrero, E Campa, C Dellacasa, S Campana, C Foli, and M Boccadoro

13-cis retinoic acid + (OH)2 vitamin D3 + low-dose 6-thioguanine and cytarabine were tested in 26 patients with acute myeloid leukemia (AML) and in 4 patients with myelodysplastic syndrome (MDS) (median age 72.5), ineligible for standard chemotherapy. The response rate was 50%, with 27% complete remission. The median survival of the whole group and responders was 7.5 (1-47+) and 16.5 months (3.5-47+), respectively.


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ASH ANNUAL MEETING ABSTRACTSHome page
D. Ferrero, C. Dellacasa, M. Bonferroni, M. Grasso, E. Campa, V. Giai, M. Genuardi, and M. Boccadoro
A Maintenance Therapy with Differentiating Agents and Low-Dose Chemotherapy Increases Remission Duration and Survival in High Risk AML and MDS Patients.
Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 4614 - 4614.
[Abstract]




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