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Haematologica, Vol 89, Issue 5, 624-626
Copyright © 2004 by Ferrata Storti Foundation

Letter

Bcl-6 gene mutations in primary cutaneous B-cell lymphomas

U Gianelli, A Cerri, B Cassani, L Moneghini, PR Raviele, E Berti, and S Bosari

We analyzed mutations in the 5' non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.




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Copyright © 2004 by the Ferrata Storti Foundation.