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Letter |
Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.
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B. M. Birmann, E. Giovannucci, B. Rosner, K. C. Anderson, and G. A. Colditz Body Mass Index, Physical Activity, and Risk of Multiple Myeloma Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1474 - 1478. [Abstract] [Full Text] [PDF] |
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