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Haematologica, Vol 89, Issue 6, 748-749
Copyright © 2004 by Ferrata Storti Foundation

Letter

Impact of erythropoietic activity on red cell parameters in chronic renal failure patients

C Bovy, JM Krzesinski, A Gothot, and Y Beguin

We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic activity led to a bias in red cell parameter determination. The percentage of hypochromic red blood cells, usually used as the most effective predictor of response to iron supplementation, increased following the appearance of a younger red cell population since the same Hb content in these younger, larger cells gives a lower Hb concentration.


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 Nephrol Dial TransplantHome page
C. Bovy, A. Gothot, P. Delanaye, X. Warling, J.-M. Krzesinski, and Y. Beguin
Mature erythrocyte parameters as new markers of functional iron deficiency in haemodialysis: sensitivity and specificity
Nephrol. Dial. Transplant., April 1, 2007; 22(4): 1156 - 1162.
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