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Haematologica, Vol 89, Issue 6, 757-758
Copyright © 2004 by Ferrata Storti Foundation

Letter

Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats - an effect of tranexamic acid

H Asakura, Y Sano, M Yamazaki, E Morishita, K Miyamoto, and S Nakao

We clarified the role of fibrinolysis in tissue-factor (TF)-induced rat disseminated intravascular coagulation (DIC) using tranexamic acid (TA). TA suppressed the elevation in D-dimer levels normally observed following TF-induced DIC, and an increase in organ dysfunction was seen. Enhanced fibrinolysis plays an important role in preventing the development of organ failure in TF-induced DIC.




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Copyright © 2004 by the Ferrata Storti Foundation.