Haematologica
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Haematologica, Vol 89, Issue 8, 1013-1015
Copyright © 2004 by Ferrata Storti Foundation

Letter

Molecular diagnosis of leukemic cerebrospinal fluid cells in children with newly diagnosed acute lymphoblastic leukemia

CA Scrideli, RP Queiroz, OM Takayanagui, JE Bernardes, EV Melo, and LG Tone

Cytomorphology and IgH/T-cell receptor g clonal gene rearrangements detected by polymerase chain reaction (PCR) homo/heteroduplex analysis and direct sequencing were evaluated in cerebrospinal fluid (CSF) free of red-blood cells at diagnosis of 37 children with acute lymphoblastic leukemia. Molecular CSF involvement was greater as detected by molecular analysis than observed by morphologic criteria (45.9% vs 5.4%). The 4-year event-free survival was lower in the group with molecularly detected CSF involvement (p = 0.01).




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Copyright © 2004 by the Ferrata Storti Foundation.