Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuchenbauer, F
Right arrow Articles by Schnittger, S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuchenbauer, F
Right arrow Articles by Schnittger, S
Haematologica, Vol 90, Issue 12, 1617-1625
Copyright © 2005 by Ferrata Storti Foundation

Journal Article

Detailed analysis of FLT3 expression levels in acute myeloid leukemia

F Kuchenbauer, W Kern, C Schoch, A Kohlmann, W Hiddemann, T Haferlach, and S Schnittger

Department of Internal Medicine III, Ludwig-Maximilians University of Munich, University Hospital Grosshadern, Munich, Germany.

BACKGROUND AND OBJECTIVES: FLT3 mutations are found in up to 30% of cases of acute myeloid leukemia (AML). Although new FLT3 mutations are being increasing by investigated, the role of FLT3 expression levels in wild type as well as in mutated FLT3 has only been infrequently addressed. DESIGN AND METHODS: To further evaluate the role of FLT3 in AML we investigated FLT3 expression levels in 207 adult AML patients and 8 healthy donors by real-time polymerase chain reaction (PCR). The expression levels were correlated with clinical parameters, FAB types, cytogenetics, flow cytometry, microarray analysis, FLT3 mutations, further molecular aberrations and prognosis. RESULTS: FLT3 expression levels were different in certain FAB types with increasing levels in the following order: M3


This article has been cited by other articles:


Home page
 BloodHome page
F. Dicker, C. Haferlach, W. Kern, T. Haferlach, and S. Schnittger
Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia
Blood, August 15, 2007; 110(4): 1308 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
F. P.G. Silva, A. Lind, G. Brouwer-Mandema, P. J.M. Valk, and M. Giphart-Gassler
Trisomy 13 correlates with RUNX1 mutation and increased FLT3 expression in AML-M0 patients
Haematologica, August 1, 2007; 92(8): 1123 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
R. Riccioni, D. Diverio, G. Mariani, S. Buffolino, V. Riti, E. Saulle, E. Petrucci, M. Cedrone, F. Lo-Coco, R. Foa, et al.
Expression of Tie-2 and Other Receptors for Endothelial Growth Factors in Acute Myeloid Leukemias Is Associated with Monocytic Features of Leukemic Blasts
Stem Cells, August 1, 2007; 25(8): 1862 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Mrozek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
Blood, January 15, 2007; 109(2): 431 - 448.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2005 by the Ferrata Storti Foundation.