Haematologica
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Haematologica, Vol 90, Issue 12, 1665-1671
Copyright © 2005 by Ferrata Storti Foundation

Comparative Study

Single-dose pegfilgrastim for the mobilization of allogeneic CD34+ peripheral blood progenitor cells in healthy family and unrelated donors

F Kroschinsky, K Holig, K Poppe-Thiede, K Zimmer, R Ordemann, M Blechschmidt, U Oelschlaegel, M Bornhauser, G Rall, C Rutt, and G Ehninger

University Hospital Dresden, 1st Medical Department, Dresden, Germany. kroschinsky@mk1.med.tu-dresden.de

BACKGROUND AND OBJECTIVES: Short-term treatment with granulocyte colony-stimulating factor (G-CSF) has been established as the standard regimen for mobilizing allogeneic peripheral blood progenitor cells (PBPC) from healthy donors. The pegylated form of filgrastim (pegfilgrastim) has a longer elimination half-life because of decreased serum clearance and might be a convenient alternative for stem cell mobilization. DESIGN AND METHODS: Twenty-five family (n=15) or unrelated (n=10) healthy donors received a single-dose of 12 mg pegfilgrastim for mobilization of allogeneic PBPC. Donors with inadequate mobilization (blood CD34+ cells


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