Haematologica
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Haematologica, Vol 90, Issue 12, 1699-1701
Copyright © 2005 by Ferrata Storti Foundation

Letter

The prognostic value of cN-II and cN-III enzymes in adult acute myeloid leukemia

CM Galmarini, E Cros, X Thomas, L Jordheim, and C Dumontet

We analyzed the expression of deoxycytidine kinase (dCK), UMP/CMP-kinase (UMP/CMP-K), nucleotide diphosphokinase (NDPK-B) and 5'-nucleotidases cN-II, cN-III, cdN and mdN by quantitative polymerase chain reaction at diagnosis in leukemic blasts from 96 patients with acute myeloid leukemia (AML) treated with ara-C. Our results show that high mRNA levels of cN-II and low mRNA levels of cN-III are correlated with a worse clinical outcome and suggest that these enzymes may have a role in sensitivity to ara-C in AML patients.


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