Haematologica
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Haematologica, Vol 90, Issue 12, 1711-1713
Copyright © 2005 by Ferrata Storti Foundation

Comparative Study

The prognostic value of interim positron emission tomography scans combined with immunohistochemical data in diffuse large B-cell lymphoma

PA Fields, G Mikhaeel, M Hutchings, J van der Walt, T Nunan, and SA Schey

The treatment of hematologic malignancies is moving towards risk-stratified directed therapy, whereby treatment is based on the disease's biological characteristics and response to treatment. We investigated whether BCL2 and BCL6 status could add to the prognostic information yielded by an interim positron emission tomography (PET) scan in the ability to predict outcome. Negative interim scans and BCL2-negative status correlated with continuing remission (p<0.005) at a median follow up of 24 months.


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