Haematologica
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Haematologica, Vol 90, Issue 2, 262-264
Copyright © 2005 by Ferrata Storti Foundation

Letter

Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes

G Rege-Cambrin, E Giugliano, L Michaux, M Stul, P Scaravaglio, A Serra, G Saglio, and A Hagemeijer

In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.




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Copyright © 2005 by the Ferrata Storti Foundation.