Haematologica
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Haematologica, Vol 90, Issue 2, 266-268
Copyright © 2005 by Ferrata Storti Foundation

Letter

Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies

F Forconi, D Raspadori, M Lenoci, and F Lauria

Surface expression of CD27 was evaluated in 75 mature leukemic B-cell neoplasms. All cases other than hairy cell leukemia (HCL) expressed CD27. Intensity was significantly higher in chronic lymphocytic leukemia. Lack of CD27 in 17/17 HCL contrasted with expression of this marker in 5/5 splenic lymphomas with villous lymphocytes. Lack of CD27 is a new distinctive feature of HCL among B-cell malignancies.


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F. Forconi, E. Sozzi, D. Rossi, S. S. Sahota, T. Amato, D. Raspadori, L. Trentin, L. Leoncini, G. Gaidano, and F. Lauria
Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia
Haematologica, May 1, 2008; 93(5): 697 - 705.
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