Haematologica
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Haematologica, Vol 90, Issue 2, 274-275
Copyright © 2005 by Ferrata Storti Foundation

Letter

AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type

C Chow, AY Liu, WS Chan, KI Lei, WY Chan, and AW Lo

Phosphorylated AKT has been detected in extranodal NK/T-cell lymphoma, nasal type (ENTL). Either interleukin-2 (IL-2) or interleukin-15 (IL-15) could prevent AKT dephosphorylation and apoptosis in the NK-92 cell line model. IL-15, but not IL-2, was preferentially elevated in patients' serum. AKT and IL-15 may be important in ENTL tumor survival.




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Copyright © 2005 by the Ferrata Storti Foundation.