Haematologica
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Haematologica, Vol 90, Issue 2, 275-278
Copyright © 2005 by Ferrata Storti Foundation

Letter

Lack of receptor activator of nuclear factor-kB ligand (RANKL) expression and functional production by human multiple myeloma cells

N Giuliani, S Colla, F Morandi, S Barille-Nion, and V Rizzoli

The direct expression and production of the critical osteoclastogenic factor, the receptor activator of NF-kB ligand (RANKL), is a matter of controversy. In this study we definitively demonstrate by both qualitative and quantitative polymerase chain reaction analysis that human myeloma cells do not express significant levels of RANKL mRNA or produce RANKL able to stimulate osteoclast formation.


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