Haematologica
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Haematologica, Vol 90, Issue 3, 400-401
Copyright © 2005 by Ferrata Storti Foundation


Letter

Differential expression of vascular endothelial growth factor and its receptors in hematopoietic and fatty bone marrow: evidence that neuropilin-1 is produced by fat cells

Z Belaid, F Hubint, C Humblet, J Boniver, B Nusgens, and MP Defresne

Vascular endothelial growth factor (VEGF), its receptors (VEGFR-1, VEGFR-2) and neuropillin-1 (NRP-1) are expressed at variable levels in bone marrow. NRP-1expression is higher in fatty bone marrow than in hematopoietic marrow. Adipocytes are responsible for NRP-1 expression suggesting that they may play a role in hematopoiesis by producing NRP-1 or that NRP-1 may regulate adipocyte activity.


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