Haematologica
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Haematologica, Vol 90, Issue 3, 403-405
Copyright © 2005 by Ferrata Storti Foundation

Letter

Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line

W Gu, Z Chen, S Hu, H Shen, G Qiu, and X Cao

The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.


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