Haematologica
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Haematologica, Vol 90, Issue 3, ECR17-ECR17
Copyright © 2005 by Ferrata Storti Foundation

Case Reports

Catastrophic antiphospholipid syndrome: atypical presentation in the setting of chronic graft versus host disease: case report and review of the literature

KM Kasamon, CI Drachenberg, AP Rapoport, and A Badros

Department of Hematology, Greenebaum Cancer Center, University of Maryland, Baltimore 21201, USA.

A 44-year-old female developed a catastrophic thrombotic syndrome following allogeneic stem cell transplantation for acute lymphoblastic leukemia. In the context of chronic graft versus host disease, she developed a lethal multi-system thrombotic state as evidenced by stroke, renal failure and cardiac thrombi in association with elevated anticardiolipin antibody. The case is discussed in the framework of the existing literature and derives clinical practice recommendations for this rare but clinically devastating entity.




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Copyright © 2005 by the Ferrata Storti Foundation.