Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Traverse-Glehen, A
Right arrow Articles by Salles, G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Traverse-Glehen, A
Right arrow Articles by Salles, G
Haematologica, Vol 90, Issue 4, 470-478
Copyright © 2005 by Ferrata Storti Foundation

Journal Article

Analysis of VH genes in marginal zone lymphoma reveals marked heterogeneity between splenic and nodal tumors and suggests the existence of clonal selection

A Traverse-Glehen, F Davi, E Ben Simon, E Callet-Bauchu, P Felman, L Baseggio, S Gazzo, C Thieblemont, C Charlot, B Coiffier, F Berger, and G Salles

Equipe Accueil 3737 Pathologie des Cellules Lymphoides, Universite Claude Bernard, France.

BACKGROUND AND OBJECTIVES: To clarify the relationship between splenic (SMZL) and nodal marginal zone (NMZL) lymphomas, we analyzed immunoglobulin variable heavy chain (VH) gene usage and mutation patterns in these tumors. DESIGN AND METHODS: VH genes were cloned and sequenced from 49 lymphoma samples (35 SMZL and 14 NMZL). RESULTS: A biased usage of VH gene was found with overrepresentation of VH1 in SMZL cases (13/35) and VH4 in NMZL cases (7/14). Evidence for antigen driven mutations was identified in 8 SMZL and 4 NMZL cases. Three cases out of 18 with clones analyzed from spleen and peripheral blood demonstrated intra-clonal diversity, with evidence of clonal selection in one case, indicating the possibility of antigen-driven clonal expansion. Eleven SMZL cases (31%) but only 2 NMZL (14%) cases were unmutated. No differences in clinical outcome and overall survival were found between the unmutated and mutated cases. INTERPRETATION AND CONCLUSIONS: The pattern of somatic mutation and the VH gene segment usage appear to differ between SMZL and NMZL, suggesting that these are distinct pathological entities. Moreover, a biased usage of certain sequences suggests that tumor cells in SMZL may be subjected to antigen selection.


This article has been cited by other articles:


Home page
 BloodHome page
M. Colombat, H. Mal, C. Copie-Bergman, J. Diebold, D. Damotte, P. Callard, M. Fournier, J.-P. Farcet, M. Stern, and M.-H. Delfau-Larue
Primary cystic lung light chain deposition disease: a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34/IGKV1 receptor
Blood, September 1, 2008; 112(5): 2004 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Traverse-Glehen, L. Baseggio, E. C. Bauchu, D. Morel, S. Gazzo, M. Ffrench, A. Verney, D. Rolland, C. Thieblemont, J.-P. Magaud, et al.
Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity?
Blood, February 15, 2008; 111(4): 2253 - 2260.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2005 by the Ferrata Storti Foundation.