Haematologica, Vol 90, Issue 5, 691-693
Copyright © 2005 by Ferrata Storti Foundation
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7
S Knipp,
B Hildebrandt,
J Richter,
R Haas,
U Germing,
and
N Gattermann
We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders. Long-term treatment with azathioprine seems to be associated with an increased risk of MDS and subsequent leukemic transformation.