Haematologica
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Haematologica, Vol 90, Issue 5, 695-696
Copyright © 2005 by Ferrata Storti Foundation

Evaluation Studies

Limited value of FLT3 mRNA expression in the bone marrow for prognosis and monitoring of patients with acute myeloid leukemia

B Kainz, C Fonatsch, I Schwarzinger, WR Sperr, U Jager, and A Gaiger

We studied wild-type FLT3 mRNA expression at diagnosis in bone marrow samples from 85 patients with acute myeloid leukemia (AML), 23 of whom were in complete remission, and determined its utility as a marker for minimal residual disease (MRD). We conclude that FLT3 expression is of limited value as a prognostic marker and for MRD monitoring.


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