Haematologica
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Haematologica, Vol 90, Issue 7, 977-979
Copyright © 2005 by Ferrata Storti Foundation

Letter

Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia

RN Costa, N Conran, DM Albuquerque, PH Soares, ST Saad, and FF Costa

Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.




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Copyright © 2005 by the Ferrata Storti Foundation.