Haematologica
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Haematologica, Vol 90, Issue 7, 982-984
Copyright © 2005 by Ferrata Storti Foundation

Letter

The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia

MT Voso, F D'Alo', D Gumiero, F Guidi, S Hohaus, and G Leone

Polymorphisms in carcinogen- and drug-metabolizing enzymes may increase the risk of acute myeloid leukemia (AML) and may influence prognosis. We report that the polymorphic variant of the cytochrome P450 CYP1A1*2A, present in 11.3% of patients, is an independent unfavorable prognostic factor for failure-free and overall survival in patients with AML.




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Copyright © 2005 by the Ferrata Storti Foundation.