Haematologica
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Haematologica, Vol 90, Issue 7, 992-994
Copyright © 2005 by Ferrata Storti Foundation

Letter

Detection of tumor-derived antigen receptor DNA by polymerase chain reaction in the serum of patients with B-cell chronic lymphocytic leukemia

MA Catherwood, JP Wall, TC Morris, and HD Alexander

Tumor-derived DNA is detectable in the serum of patients. In this study, tumor derived and mononuculear cell DNA from 50 patients with B-cell chronic lymphocytic leukemia (B-CLL) was amplified by polymerase chain reaction (PCR) and analyzed using polyacrylamide electrophoressis and Genescan analysis. DNA was demonstrated in 86% of serum samples. Genescan analysis has significantly enhanced the sensitivity and specificity of detection of tumor-derived DNA.




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Copyright © 2005 by the Ferrata Storti Foundation.