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Haematologica, Vol 90, Issue 9, 1267-1268
Copyright © 2005 by Ferrata Storti Foundation

Comparative Study

The role of lactadherin in the phagocytosis of phosphatidylserine-expressing sickle red blood cells by macrophages

SK Dasgupta and P Thiagarajan

Lactadherin is a phosphatidylserine-binding glycoprotein secreted by macrophages. Less than 0.5% of normal circulating red cells showed any binding to lactadherin. However, the red cells from patients with sickle cell disease showed 2 to 10-fold increases in lactadherin binding. Further, lactadherin stimulated the phagocytosis of sickle red blood cells by macrophages suggesting a potential role in sickle red cell clearance.


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