Haematologica
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Haematologica, Vol 90, Issue 9, 1277-1279
Copyright © 2005 by Ferrata Storti Foundation

Comparative Study

Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis

J Zhou, R Meng, X Sui, L Meng, J Jia, and B Yang

We studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) on apoptosis and differentiation of several cell lines in vitro. We also studied the same effects of fluctuating vs constant concentrations of As2O3 in vivo in patients treated with daily 3-hour fast infusions or daily slow, continuous infusions. Intracellular concentrations of arsenic and apoptosis rate were higher whereas differentiation was reduced in cells exposed to constant concentrations of As2O3.




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Copyright © 2005 by the Ferrata Storti Foundation.