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Haematologica, Vol 90, Issue 9, 1279-1281
Copyright © 2005 by Ferrata Storti Foundation

Comparative Study

Expression of the glucocorticoid receptor and its isoforms in relation to glucocorticoid resistance in childhood acute lymphocytic leukemia

WJ Tissing, M Lauten, JP Meijerink, ML den Boer, JW Koper, P Sonneveld, and R Pieters

In vitro prednisolone resistance is a poor prognostic factor in the treatment of childhood acute lymphoblastic leukemia (ALL). In a cohort of 54 children with ALL, a lower expression of the glucocorticoid receptor (GR), but not the relative expression levels of the GR-alpha, GR-beta and GR-P isoforms, was associated with in vitro prednisolone resistance.


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