Haematologica
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Haematologica, Vol 90, Issue 9, 1285-1286
Copyright © 2005 by Ferrata Storti Foundation

Comparative Study

The relevance of sequence insertions in the Mcl-1 promoter in chronic lymphocytic leukemia and in normal cells

S Coenen, B Pickering, KN Potter, PW Johnson, FK Stevenson, and G Packham

We measured the frequency of insertions in the Mcl-1 promoter in chronic lymphocytic leukemia (CLL) and in normal individuals. Insertions were found in 37/54 (69%) of the CLL samples. However, insertions were not associated with prognostic markers and were also detected in 38/66 (58%) of normal controls and in normal cells isolated from CLL patients. Thus, Mcl-1 insertions are not acquired during leukemogenesis and are unlikely to play an important role in this disease.


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