Haematologica
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Haematologica, Vol 91, Issue 10, 1396-1399
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

Suppression of RANTES in children with Plasmodium falciparum malaria

T Were, JB Hittner, C Ouma, RO Otieno, AS Orago, JM Ong'echa, JM Vulule, CC Keller, and DJ Perkins

Department of Pathology, School of Health Sciences, Kenyatta University, Nairobi, Kenya.

Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood malaria. We found that RANTES is decreased during severe MA (p<0.01), and associated with suppression of erythropoiesis (p<0.05) and malaria-induced thrombocytopenia (p<0.05). These findings suggest that thrombocytopenia may be a source of reduced RANTES which may contribute, at least in part, to suppression of erythropoiesis in children with malarial anemia.




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Copyright © 2006 by the Ferrata Storti Foundation.