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Haematologica, Vol 91, Issue 10, 1426-1427
Copyright © 2006 by Ferrata Storti Foundation

Case Reports

The effects of rituximab treatment during pregnancy on a neonate

B Friedrichs, M Tiemann, H Salwender, K Verpoort, MK Wenger, and N Schmitz

A 35-year old woman developed Burkitt's lymphoma and was treated with rituximab and CHOP therapy early during pregnancy. Monitoring of rituximab concentrations and B-cell counts in the child revealed a transient complete B-cell depletion associated with high rituximab cord blood concentrations. B-cell recovery was fast, showing a regular immunophenotype without loss of CD20 antigen, no functional deficits and adequate vaccination IgG titers.


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Copyright © 2006 by the Ferrata Storti Foundation.