Haematologica
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Haematologica, Vol 91, Issue 10, 1430-1431
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

Karyotype complexity and VH gene status in B-cell chronic lymphocytic leukemia

G Mehes, G Kovacs, B Kajtar, A Lacza, A Varnai, H Losonczy, and L Pajor

B-cell chronic lymphocytic leukemia-related genomic changes were analyzed by karyotyping, fluorescence in situ hybridization, and V(H) gene sequencing in a prospective clinical evaluation. The V(H) mutational status correlated with high-risk cytogenetic aberrations while no such relation could be demonstrated for specific VH gene usage (V(3-21) and V(1-69)). Complex karyotypes were highly indicative of disease progression.




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Copyright © 2006 by the Ferrata Storti Foundation.