Haematologica
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Haematologica, Vol 91, Issue 11, 1579-1580
Copyright © 2006 by Ferrata Storti Foundation

Comparative Study

The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells

E Ocana, I Gonzalez-Garcia, NC Gutierrez, F Mora-Lopez, JA Brieva, and A Campos-Caro

The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.




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Copyright © 2006 by the Ferrata Storti Foundation.